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In cultured tendon fibroblasts, Chang et al., J Appl Physiol 2011 reported that BPC-157 accelerated cell outgrowth from tendon explants, improved survival under oxidative (H 2 O 2 ) stress and increased fibroblast migration in a dose-dependent manner, effects the authors linked to the FAKpaxillin pathway

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Together these compounds engage complementary signaling pathways allowing researchers to examine tissue repair mechanisms and actin cytoskeletal dynamics in controlled laboratory models

DOI: 10.1016/j.bbadis.2011.10.003