LA maintains the cellular antioxidant state indirectly through activating the NRF2 pathway, and the NRF2 pathway governs the expression of antioxidant genes (such as -glutamylcysteine synthetase (-GCL), NAD(P)H quinone oxidoreductase 1 (NQO-1), and superoxide dismutase (SOD)) for enhancing the cell's antioxidant capacity and anti-inflammatory response [34, 35]
Zhu LQ, Wang SH, Ling ZQ, Wang DL, Wang JZ
a third of patients deteriorate to being house or bedbound (24, 2931), impacting activities of daily living, socialising, family life, emotional wellbeing, work, and education (23)
Clinical studies help clarify the connection: In simple terms: the trigger is the speed of weight loss, not tirzepatide itself
2026 Hillary Lin, MD All rights reserved This content is educational and isn't medical advice
Rezende MC, Palma MI, Chaves BS, Fontes PA, Rocha JG, Rezende JRP