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Someone who was stable on tirzepatide 10 mg with excellent tolerability can reasonably start semaglutide at 0.5 to 1 mg rather than 0.25 mg

Mitochondrial permeability transition pore: A potential drug target for neurodegeneration

The short answer is that all three injection sites are equally effective in the long run

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Yu JH, Park SY, et al

Its mechanism involves specific engagement of AMY1R and AMY3R in hindbrain and hypothalamic circuits that regulate energy homeostasis, leading to preferential fat mass reduction and altered hypothalamic gene expression profiles [2]