Published peer-reviewed research has established several mechanisms through which these medications support weight management: they help reduce appetite by acting on hunger signals in the brain, they slow gastric emptying which promotes a feeling of fullness after meals and they help regulate post-meal blood sugar responses
In a clinical study involving patients with type 2 diabetes, an almond-based diet with a low-carbohydrate content, which had been previously shown to possess marked prebiotic properties [110, 111], resulted in augmentation of the number of SCFA-producing bacteria species, such as Roseburia , Ruminococcus and Eubacterium , which led to an increase in fasting blood GLP-1 levels and also promoted antidepressive effects after three months [112]
Nat Genet
371 In a study examining the effects of GLP-1RA on osteoporosis induced by ovariectomy in aged rats, administering exendin-4 for 16 weeks prevented deterioration of the trabecular microarchitecture and increased bone strength
Abbreviations DPP-4: Dipeptidylpeptidase-4 GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 HbA1C: Hemoglobin A1C HDL-C: High-density lipoprotein cholesterol LDL-C: Low-density lipoprotein cholesterol T2DM: Type 2 diabetes mellitus References Elrick H, Stimmler L, Hlad CJ, Arai Y
More than half of Americans taking GLP-1s say it was difficult to afford
