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Iranian J Reprod Med

Advances in nanotechnology, lipid-based carriers, and mucosal absorption represent active areas of study to bridge the gap between oral feasibility and systemic efficacy

Studies in mice and humans showed that GLP-1 liraglutide acts directly and indirectly in LDL and VLDL catabolism, increases lipoprotein lipase gene expression responsible for TAG hydrolysis, and reduces apolipoprotein B48, diacylglycerol O -acyltransferase 1, and microsomal transfer protein gene expression, all of which are involved in chylomicron synthesis [77, 78]

specific study formulations fall outside the scope of this discussion

This termination underscores the ongoing challenges in recruitment and the potential lack of clinical benefit for unselected patients, reinforcing the necessity for precision medicine to identify specific phenotypes that may respond to bronchodilator therapy