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Evidence-based protocols

For this reason, SUs should not be the first-line drug election for obese Type 2DM patients

10.1016/j.freeradbiomed.2018.05.074 75 KangR.ZhuS.ZehH

A central issue in GLP-1 litigation is that the same mechanism that helps regulate appetite and glucose levels may also interfere with normal gastrointestinal motility

GLP-1 RAs may be suitable for patients with type 2 diabetes coexisting with NAFLD

He added that his surprise doesnt stem from any concerns over the mechanism of action for the two drugs, but rather because orforglipron has not gone through the extensive evaluation of adverse effects since its not approved yet