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When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity (4)

Additionally, it was demonstrated that eNAP-2 formed an enzyme-inhibitor complex with subtilisin A and proteinase K but not with other tested proteinases

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The decision of when to start B12 injections is individual and depends on factors like the severity of the deficiency, the underlying cause, and the patients health status

However this is usually mild and will wear off quite quickly.

Further investigations are underway regarding protein-based approaches relying on other hormonal effects for effective weight loss