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Biomarker Effects Were Present Despite clinical failure, semaglutide showed biological activity: CSF biomarkers including pTau181, pTau217, and others demonstrated nominally significant reductions of approximately 10% in treated patients

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doi: 10.1371/JOURNAL.PONE.0280872 67 MarroquiLDos SantosRSFlyelTGriecoFASantinIOp De BeeckAet al