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Their evaluation of the effect of GLP-1 was also aided by their access to RIAs for GLP-1 (Holst 2024)

Importantly, unlike -adrenergic stimulationinduced increases in myocardial cAMP, which enhance contractility, GLP-1 showed negative inotropic effects in rodent cardiac myocytes, implicating a compartmentalized mechanism of cAMP production away from the contractile apparatus (53)

Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids

The kidney and heart protective effects of glucagon-like peptide 1 (GLP-1) receptor agonists are not fully explained by their metabolic effects

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