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Here, we used human studies and in vitro models to demonstrate that NAPQI-derived thiomethyl metabolites identified using high-resolution mass spectrometry could serve to monitor NAPQI detoxification and elimination in patients (after intake at recommended dose or after intoxication), and to study inter-individual variability in NAPQI production

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Both are expressed in the brain and retina

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In addition, the purity of raw materials, formulation concentrations, and delivery systems vary between studies