Marzioni M, Alpini G, Saccomanno S, Candelaresi C, Venter J, Rychlicki C, et al
At the moment, the only legal way to access retatrutide is through an authorised clinical trial
For example, with semaglutide (Ozempic), the recommended titration schedule for type 2 diabetes involves starting with a 0.25 mg dose once weekly for four weeks, followed by an increase to 0.5 mg once weekly for at least four weeks
Researchers who have never used a GLP-1 agonist should generally start with tirzepatide or even semaglutide to understand their individual response to incretin therapy before attempting a triple agonist with higher side effect rates
Ask about currently approved alternatives
Beyond obesity and type 2 diabetes, retatrutide is under investigation for related conditions such as nonalcoholic steatohepatitis (NASH)