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In addition, activated FLSs produce large amounts of matrix metalloproteinase (MMPs) and receptor activator of nuclear factor-B ligand (RANKL), which further accelerate the degradation of intra-articular cartilage and bone tissue, leading to further bone erosion development (Ospelt et al., 2008)

Parkinsons disease, characterized by the degeneration of dopaminergic neurons and the aggregation of -synuclein, polyphenols again show promise (409)

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Thus, these studies highlight the importance of sustained stress paradigms for modeling the progressive nature of neurodegenerative diseases