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Cholesterolosis indicates the accumulation of lipid cholesterol droplets in the mucosa of the gallbladder wall

Though these are a normal part of human metabolism, they cause significant oxidative stress over time, damaging DNA inside cells and leading to premature aging

Laughlin GA, Barrett-Connor E, Criqui MH, Kritz-Silverstein D: The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study

Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging

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One study showed that, although lycopene significantly reduced clinical symptoms such as burning sensation and severity of lesion in patients with OLP, prednisolone was more effective than lycopene