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GSTs were shown to catalyze the conjugation between various xenobiotics with electrophilic centers (Figure 1) and the nucleophilic GSH, thus tagging the xenobiotic for vacuolar sequestration (Martinoia et al., 1993)

This lower retatrutide dose also means fewer GI side effects from the retatrutide itself, which is a meaningful quality-of-life improvement over the long term

In our opinion, this is mainly due to the fact that many laboratory-stage techniques are limited by safety and ethical concerns

These findings contribute to developing novel therapeutic strategies targeting AD pathology (Table 11)