Increases in renal ROS production can lead to the release of pro-inflammatory cytokines, and, if persistent, to inflammation and renal fibrosis, making OS a proven contributing factor to Chronic Kidney Disease (CKD) in both human and animal models [187,188,189,190]
Weight loss, particularly rapid weight loss often seen with these drugs, inevitably involves the loss of both fat mass and lean body mass (muscle)
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Younes A, Snell V, Consoli U, Clodi K, Zhao S, Palmer JL, Thomas EK, Armitage RJ, Andreeff M
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IL-1 and IL-18, two crucial pro-inflammatory cytokines synthesized during pyroptosis regulation, are implicated in the pathogenesis of inflammatory responses in renal resident cells due to their association with the expression of chemoattractant cytokines and adhesion molecules (119)