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Afferent fibres detect luminal nutrients in the gut, mechanical stretch, inflammatory mediators, microbial metabolites, and enteroendocrine hormone release (CCK, GLP-1, PYY, serotonin)

Its crucial to watch for serious reactions, including ongoing abdominal discomfort or changes in urination, and to seek prompt medical assistance if these arise

Levy, S., Duda, M., Haber, N

By middle age, these levels fall to about half of what you had in your youth

Management: Limit use to 46 week cycles with at least equal time off Consider using GH peptides like GHRP2 or CJC1295 during off cycles to maintain baseline IGF-1 activity Risk of Unwanted Growth (Organs, Gut, Tumors) Long-term, excessive IGF1 can theoretically increase the risk of visceral organ growth , insulin resistance , or even tumor promotion , due to its role in cell proliferation

Am J Physiol-Gastrointest Liver Physiol