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100 nM MitoQ on its own was significantly cytotoxic at day 2 and 3, an effect which was also lessened by downregulation of MYCN ( Figures 1A, C )

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Our results suggest that epitalon has a positive effect on hTERT expression and telomerase activity in normal cells (IBR3 and HMEC), whereas in cancer cells (BT474 and 21NT), hTERT is elevated however, telomerase activity is not significantly enhanced

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However, the full spectrum of probable adverse unfavorable effects remains unclear

1 We need NAD+ for everything from repairing DNA and pumping blood to contracting muscles and helping our mitochondria turn food into fuel, keeping our cellular engines running smoothly