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Obesity Reviews, 22(5), e13245

In most cases, the increases in GSH levels were dose- and time-dependent, indicating that the higher dose and longer duration of supplementation were associated with greater increases in GSH stores

It carves out several exceptions: uncontrolled hyperthyroidism, recent thyroid surgery, thyroid cancer or elevated calcitonin, where it says to avoid GLP-1 therapy or work through the risks with an endocrinologist first

Side effects were similar to other GLP-1s

It is important to note that tirzepatide is not an approved anxiety treatment, and patients should not discontinue psychiatric medications without medical guidance

HbA1c levels decreased from 39.3 to 36.6, indicating better glycaemic control, while average CRP levels fell from 7.8 to 6.9, signifying reduced inflammation