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FDA approval was based on the SOUL cardiovascular outcomes trial (CVOT) that demonstrated a 14% relative reduction in risk of MACE in patients treated with Rybelsus 14 mg orally once daily for approximately 5 years compared to those who received placebo

Some users on weekly GLP-1 programs may be able to take a missed dose within 1-2 days of the scheduled time

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Importantly, overexpression of the GLP-1 metabolites GLP-1(937) and GLP-1(2837), which do not activate the classical GLP-1R, showed similar vascular protective effects, suggesting receptor-independent effects of GLP-1 (3)

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