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The study enrolled 1,961 participants with a BMI of 30 kg/m 2 or greater (or 27 kg/m 2 in persons with one or more weight-related coexisting conditions) who did not have diabetes and were randomly assigned to once-weekly 2.4 mg subcutaneous semaglutide or placebo plus lifestyle intervention for 68 weeks
A 2014 JAMA trial by Stanley et al
This decline is accelerated by external factors like UV exposure and internal factors like stress
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