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4.1 Trial evidence: recording and limitations of taste-related outcomes in RCTs and PROs In randomised controlled trials (RCTs), primary outcomes are typically focused on body weight and metabolic endpoints, whereas eating-experience-related outcomes are rarely included as prespecified measures and are more often captured only sporadically as adverse events (AEs) (69)

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The results of the only study comparing the efficacy of intensive insulin therapy with that of plasmapheresis are still unknown at the time of publication of these recommendations [271]