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These modifications collectively address the major limitations of natural amylin - its tendency to aggregate into toxic fibrils, rapid degradation, and poor pharmacokinetic properties - while preserving and enhancing its beneficial metabolic effects

Hyejin Ham (GIST Department of Chemistry) for technical assistance with the cellular experiments

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The highest fold change in the gene level - approximately 44 times higher in IL-8 expression, was observed in 580 M CuCl 2 treated cells when compared to control

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