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By crossing the blood-brain barrier, DSIP acts at the core of neural and systemic balance, enabling a multidimensional therapeutic impact ( 8, 9 )

8 It's an opportunity to practice listening to true hunger and fullness cues without the interference of constant cravings or habitual thoughts about food

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In the CNS, endocannabinoids mediate retrograde signaling that begins with the synthesis of 2-AG or AEA in the postsynaptic membrane