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Compared with vehicle-treated obese mice, the treated animals showed reductions in body-weight measures, white-adipose mass and adipocyte size

ShimizuTIshikawaTSugiharaEKuninakaSMiyamotoTMabuchiYet al

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Similar concentrations have resulted in reduced mTOR activity in canine tumor cells.[52] Though rapamycin has previously been administered to dogs in other studies, this study is unique in the duration of treatment with a lower dose than previously described

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