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This condition may lead to deterioration in occupational, social or other critical performance domains or clinically severe distress

Paracetamol Effect of Early Exposure on Neurotransmission, Spatial Memory and Motor Performance in Rats

Proc Natl Acad Sci U S A 2011;108:8674-9

The experiment therefore supports pathway involvement but does not establish that receptor internalization itself is the necessary causal event

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