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The relative risks of incident microvascular events showed subgroup variations, with SGLT2i being associated with a decreased risk than GLP1-RA among those expected to gain glycemic benefits with SGLT2 inhibitors

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Advances in half-life extension and controlled-release strategies substantially weaken this rationale for abandonment

(PubMed) Stephenson CM, Levin RD, Spector T, Lis CG