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Improves Insulin Sensitivity and Glucose Regulation MOTSc increases the translocation of GLUT4 (glucose transporter) to muscle cells, enhancing glucose uptake without needing insulin spikes

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Nothing about the dose size changes across phases in the documented protocol only the frequency changes

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Surprisingly, the SURMOUNT-5 trial found that fewer people discontinued tirzepatide due to side effects (2.7%) compared to semaglutide (5.6%)