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After a recovery period of 3 days, AT-NC and AT-SIRT3OE mice were randomly separated into two groups, each 6 mice, and fed with an HFD (calorie 4.5 kcal/g, Trophic Animal Feed High-Tech Co., Nantong, Jiangsu, China) and regular chow diet (RD, calorie 2.35 kcal/g), respectively, for consecutive 13 weeks [35]

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