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Human studies are still to be conducted to verify similar effects in human

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While the changes in heart rate were minimal, this could indicate improved myocardial efficiency, potentially enhancing the cardiovascular systems ability to meet the increased exercise demands

PMID: 27186127 Citations are provided for research reference

A prespecified analysis found the kidney effect to be directionally consistent regardless of baseline SGLT2i use, with no significant treatment-by-subgroup interaction, although only a small minority of participants were taking an SGLT2i at entry, so the combination subgroup was underpowered and does not by itself establish additive benefit