repurposing semaglutide and liraglutide for alcohol use disorder PDF) Muting Alcohol Behaviors Using GLP-1

Balb/c mice used in this study were purchased from the Laboratory Animal Center of Shanghai Lingchang Biotechnology

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The peptide is constructed on a GIP receptor backbone with non-coded amino acid residues (Aib2, Aib20, aMeL13) and a C20 fatty diacid moiety that enables albumin binding, extending pharmacokinetic half-life for once-weekly administration in research settings

Reduction and Alkylation : Disulfide bonds (if present in other peptides) were reduced with DTT and alkylated with iodoacetamide (not necessary in Semaglutide but part of standard workflow)

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Simple carbohydrates tend to have a higher glycemic index