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For sustained benefits, healthcare providers may recommend maintaining a regular injection schedule

That flexibility is uncommon among peptides

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As an example, the applicant cited language from the Uretero1 TM decision in which CMS agreed that the device met the criterion for substantial clinical improvement, which stated that while comparative studies between Uretero1 TM and other disposable devices would be helpful, CMS agreed that the evidence demonstrating improved outcomes and reduced patient risk associated with the disposable device in comparison with reusable devices represented substantial clinical improvement (87 FR 71932)

For peptide research, that means faster degradation and higher contamination risk

These risks are exactly why an intramuscular injection is safer given by a trained clinician than self-administered at home