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- Evidence: Meta-analysis: 91 placebo-controlled trials, 107,910 patients Retrospective cohort study: 2.2M users via FDA Sentinel System No signal for SI/B, anxiety, depression, irritability, or psychosis - Action: FDA requesting removal of SI/B warning from Wegovy, Saxenda, and Zepbound labeling

Nov 13 2023;12(22)doi:10.3390/foods12224116 Mubki T, Rudnicka L, Olszewska M, Shapiro J

Carnosine acts as an antioxidant under physiological conditions as well as in models of induced oxidative damage

Zhou et al., 2017)

Rutaecarpine has been shown to suppress inflammatory responses by inhibiting the expression of adhesion molecules like ICAM-1 and VCAM-1, which are often upregulated during inflammatory conditions (Lee et al., 2021)

The EGR-1/NAB2 feedback regulatory loop appears to create self-sustaining repair programs, explaining why effects continue well after administration stops