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Research shows that GLP-1 medications like semaglutide can lead to dramatic early weight loss, but plateaus typically occur after several months, requiring a new, physician-guided approach for continued success

However, both groups generally benefit from structured routines that support: In many cases, simple and repeatable habits are easier to maintain long-term than overly complicated supplement routines

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When to Speak to Your Doctor or Prescriber Seek urgent medical attention for severe abdominal pain, persistent vomiting, or jaundice

Never share injection pens with others, even if you change the needle

(This analysis does not include all GLP-1s covered by Medicare, only those products with more recent FDA approvals that are also approved as weight loss medications.) Spending on Ozempic alone increased substantially between 2021 and 2022