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Research from the LEADER and SUSTAIN trials, which tracked over 6,000 patients with type 2 diabetes, found no significant changes in thyroid function tests (TSH and free T4) in the semaglutide groups compared to placebo

In a Portuguese study, the SELENOS 105G/A promoter polymorphism (rs28665122) was strongly associated with circulating levels of cytokines such as IL-1, IL-6, and TNF-, known to be involved in the pathogenesis of HT ( Reference Schomburg and Kohrle 71 , Reference Santos, Duraes and Mendes 73 )

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If further escalation is needed, patients can increase to 14 mg once daily after 30 days on the 7 mg dose