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Since these PD-specific Syn-PTMs are abundantly present under pathological conditions and are a major constituent of LBs 30,31 , we examined their effects on chaperone function using the luciferase refolding assay

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The library was used to find two DNA aptamers, XA-PD1-78 and XA-PDL1-82, that bind with human PD-1 and PD-L1 proteins respectively