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Skipping doses or varying the timing can reduce the medications effectiveness and may lead to fluctuations in symptoms

the related published evidence on Epithalon-specific effects on melatonin comes from animal models

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Circ Res 119(2):375396 Vrvik FT, Bjrnsen T, Gonzalez AM (2021) Acute effect of citrulline malate on repetition performance during strength training: a systematic review and meta-analysis