It acts as a selective agonist at the ghrelin receptor (growth hormone secretagogue receptor type 1a, GHS-R1a), the same receptor targeted by the endogenous hormone ghrelin, to stimulate the release of growth hormone (GH) from the anterior pituitary in preclinical models
Examples include: Hand tingling from wrist compression (commonly at night) Outer thigh numbness related to compression of a superficial nerve (often positional) Foot tingling related to tight footwear or altered gait These patterns are typically localized and tied to certain positions or activities
Caffeine: If using, limit to morning only and track effect on sleep
More research is needed to fully understand how semaglutide may influence the brains reward system and how this could improve treatment outcomes for people with obesity
10.1001/archopht.1994.01090180121046 Arch
Advertising Reddit, like Facebook and Google Premium Memberships Redditors who upgrade to a premium membership at Reddit.com pay $5.99 monthly or $49.99 annually for an ad-free experience plus a few other perks