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Every hair follicle requires constant nutrient supply through tiny blood vessels called capillaries

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This migration is mediated through the FAK-paxillin pathway, a signaling cascade that controls how cells move and attach to surrounding tissue

Interestingly, AD has been associated with a dysfunction in insulin signaling in the brain

Starting at the lower end (200-250mcg) allows tolerance assessment and side effect minimization before increasing to therapeutic doses, while taking doses higher than prescribed does not necessarily lead to additional benefit and may increase the risk of side effects due to physiologic feedback mechanisms