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LRRK2 gene trigger lysosomal dysfunction and abnormal cellular response to membrane damage, leading to vesicular transport dysfunction, neuroinflammation, accumulation of alpha-synuclein, mitochondrial dysfunction and ciliary loss, ultimately leading to PD (Gustavsson et al., 2024

These patients had a 10% lower risk of all-cause dementia compared to those on metformin, with particularly notable reductions in Alzheimers disease and other non-vascular dementias

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