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For type 2 diabetes (NICE NG28), GLP-1 receptor agonists are generally considered after metformin-based therapy has proven insufficient, and can be initiated in primary care according to local formularies and prescribing arrangements

In one study, 36% of 102 IBD patients reported fractures, with five vertebral fracture cases

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This mechanism of action, according to Amgen, not only induces weight loss during treatment but also lowers the likelihood of weight regain after dosing ends