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7,8 When the multiple risk factor group (ie, those without an established cardiovascular event) was looked at on its own and meta-analysis undertaken with a similar group from CANVAS, the combined end point of cardiovascular death and hospitalisation for heart failure showed a 16% reduction (HR = 0.84, 95% CI 0.69 to 1.01), although this did not quite achieve statistical significance (p=0.06, Figure 4)