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These promising results led to the development of the first dual agonists, with tirzepatide, a GIP and GLP-1 receptor agonist, being the most prominent one

holds an academic appointment at the Icahn School of Medicine at Mount Sinai

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In the head-to-head SURPASS-2 trial (NEJM 2021), tirzepatide 15 mg beat semaglutide 1 mg on HbA1c (2.30% vs 1.86%) and weight loss (11.2 kg vs 5.7 kg)

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