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While primarily used for treating growth hormone deficiencies , Sermorelin has found off-label applications in weight management

A.et al (2009)

For patients with uncontrolled hypothyroidism, thyroid hormone replacement should be optimized first, as untreated hypothyroidism can affect glucose metabolism and weight management outcomes

Some people swear by it, while others say they saw no change

It has been investigated primarily in celiac disease, where gluten-induced tight junction disruption contributes to increased intestinal permeability