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Any perceived benefits typically relate to correction of deficiency symptoms such as fatigue, which may indirectly improve capacity for physical activity

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Moreover, IgGs are limited by their relatively large size (linkage-error) and bivalency

Cautious use of parenteral cyanocobalamin is also recommended in patients with renal impairment, including premature neonates, because of the possibility of greater aluminum accumulation, which may cause central nervous system and bone toxicity

While some individuals report weight loss following these injections, other contributing factors are highly likely