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The increased secretion of fluid into the intestines may exacerbate this effect

Half-life can vary depending on the route of administration, formulation, and individual factors

Burbacher, T

The complete search strategy for each of the databases can be found in the Supplementary Material

In 39 randomized double-blind, placebo-controlled (RDP) human clinical trials including 2,009 subjects, Pycnogenol French maritime pine bark extract supplementation for two weeks to six months has been shown to beneficially affect cardiovascular health, chronic venous insufficiency, cognition, joint health, skin health, eye health, womens health, respiratory health and allergies, oral health and sports performance

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