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A 2025 review in The Journal of Clinical Endocrinology & Metabolism explains that GLP-1 receptor agonists slow gastric emptying and small-intestinal motility, which is part of how they affect blood sugar and post-meal metabolism

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The STEP-1 Extension trial showed patients regained approximately two-thirds of lost weight within one year of stopping semaglutide, regardless of adjunctive interventions

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