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These transporters largely prevent the accumulation of drugs, drug conjugates, nucleosides, and xenobiotics in the brain [12]

Signs that require urgent medical attention: Pain in the upper right abdomen Fever or nausea Yellowing of the skin or whites of the eyes (jaundice) Do not assume it is just an upset stomach

References include the SURMOUNT-1 trial publication (Jastreboff et al., New England Journal of Medicine, 2022), the Mounjaro and Zepbound prescribing information (Eli Lilly, 2024), Liu et al., JAMA Internal Medicine, 2018 (steroid-induced hyperglycemia), and American Diabetes Association Standards of Care, 2024

It is not a controlled substance, but it is also not approved for human use