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Contraindications Do Not Use If You Have a known hypersensitivity to NAD+ or any component of the formulation Are pregnant or breastfeeding (safety has not been established) Have active cancer (theoretical concerns about supporting rapidly dividing cells) Warnings and Precautions Rate of administration: Rapid administration is associated with more intense side effects including chest tightness, shortness of breath, flushing, and nausea

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Differently, van Riet and colleagues developed a methodology where primary alveolar type 2 (AEC2) cells are first cultivated as organoids to enrich and expand the cell population before their subsequent integration into a microfluidic device (160)

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10.1016/j.metabol.2013.01.014 113 ThomasC.GioielloA.NoriegaL.StrehleA.OuryJ.RizzoG.et al (2009)

Several hold FDA approval for specific indications