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Hepatic clearance accounts for roughly 25% of total apixaban elimination, primarily through CYP3A4 with minor contributions from CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2J2 [2]

J.HaaseK.Van LooP.et al (2017)

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Mirtazapine Mirtazapine, a piperazinoazepine, antagonizes the presynaptic alpha 2 -adrenergic receptor, increasing noradrenergic and serotonergic neurotransmission

Important warning: Do not mix Zoloft with a monoamine oxidase inhibitor (MAOI) or certain pain meds

doi: 10.3389/fphar.2026.1789257 Received 16 January 2026 Revised 20 April 2026 Accepted 22 April 2026 Published 20 May 2026 Volume 17 - 2026 Edited by Cyril Ronco, Universit Cte d'Azur, France Reviewed by Finbarr P