Rare but serious side effects include pancreatitis (0.3% in trials), gallbladder problems (1.4%), and acute kidney injury (0.7%)
Inhibitors of SLC7A11 suppress cystine uptake, leading to a depletion of GSH and resulting in cell death mechanisms such as apoptosis and ferroptosis [200, 201]
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GLD-1 alone accounts for more than half of this repression, as LAG-1 level is elevated almost 3-fold in the gld-1 single null mutant, which is consistent with lag-1 mRNA being identified as a GLD-1 target in RNA pull-down experiments [44,45]
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